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What are the health functions of sesamin in sesame oil?

[Abstract]:
What are the health functions of sesamin in sesame oil? It includes regulating blood lipids, protecting liver and protecting liver, anti-oxidation, delaying aging, anti-hypertension and other health care functions.

What are the health functions of sesamin in sesame oil? It includes regulating blood lipids, protecting liver and protecting liver, anti-oxidation, delaying aging, anti-hypertension and other health care functions. The specific Sesame sesame products are introduced for you in detail.

1. Regulate blood lipids

The blood cholesterol and triglyceride levels in the human body are too high, causing atherosclerosis, which can cause a variety of diseases in the human body. High-density lipoprotein can eliminate the accumulation of cholesterol in blood vessels and increase the high-density lipoprotein content in the blood, which can prevent arteriosclerosis. Experiments have shown that sesamin can inhibit the δ-unsaturated enzyme reaction and promote the formation of a series of eicosenoic acids. Polyunsaturated fatty acids promote the excretion of steroids and bile acids, prevent the synthesis and absorption of cholesterol in the body, and avoid atherosclerosis caused by the deposition of cholesterol. China's gold has long been subjected to the effect of sesamin on hyperlipidemia in rats. The results show that sesamin is a serum total cholesterol (TG) and low-density lipoprotein (HDL) caused by feeding high-fat diet in rats. The increase in LDL-C) has a significant inhibitory effect.

2. Liver protection and liver protection

The liver is an important metabolic organ of the human body. The metabolic transformation and detoxification process of various substances entering the human body is mainly done in the liver, so the liver is easily damaged. Chemical poisons in the environment, alcohol in the diet, and iatrogenic drugs can cause liver damage. Sesamin has the function of protecting the liver and is the most concerned function. Experiments have shown that the metabolism of sesamin is mainly carried out in the liver, promotes ethanol metabolism, and improves β-oxidation of fatty acids, thereby reducing the damage of ethanol to the liver and the accumulation of fat in the liver. Japanese scholars experimented with sesamin fed a rat model of ethanol-induced liver disease. The serum analysis and histopathological examination were used to analyze the effects of sesamin on liver function. The results showed that the transaminase activity and triglyceride levels in the sesamin group were measured. There is almost no difference from the normal diet group, and the accumulation of liver fat is also reduced, which has the effect of inhibiting the formation of fatty liver. It was also confirmed that sesamin has the effect of repairing liver damage caused by carbon tetrachloride.

3. Antioxidant, delay aging

The theory of human aging free radicals believes that the human body generates free radicals in the metabolic process of life activities. Under normal circumstances, the generation and elimination of free radicals in the human body are in equilibrium, but when the free radicals are too much to lose balance, it will cause more Diseases and aging of the body. Japanese scholars have shown that sesame lignan has strong antioxidant activity in the body, eliminating organic free radicals, peroxides and hydroxyl radicals. Scholars studied the effect of sesamin on the elimination of free radicals in rat liver. The results showed that the 4-hydroxy-2,2,6,6-methylpiperidin-1-oxyl group in the liver part of the sesamin group disappeared. The speed is significantly faster. Sesamin was fed to rats and the antioxidative activity of metabolites of sesamin in bile was examined, indicating that the metabolism of sesamin in rats has a strong activity of scavenging superoxide anion and hydroxyl radicals.

4. Antihypertensive

In 1998, Matsumura et al. reported the antihypertensive effect of sesamin. They were experimented with male rats with spontaneously susceptible hypertension, and the high pressure of the rats in the sesamin feeding group was significantly inhibited during the experiment. Taiwanese scholar LeeCC et al tested the effects of sesamin on human umbilical vein endothelial cells (HUVECs) on carbon monoxide (NO) and endothelin. NO is considered to be the most important factor regulating vasodilation in the endothelial layer. ET-1 shows strong regulatory properties of contractile blood vessels in the endothelial layer. The results showed that sesamin not only increased the concentration of NO in human umbilical vein endothelial cells, but also induced the expression of eNOS synthase (eNOS) mRNA and protein. The activity of NOS was also induced in human umbilical vein endothelial cells. On the other hand, the concentration of ET-1 was inhibited in human umbilical vein endothelial cells, and the expression of endothelin-converting enzyme-1 (ECE-1) protein and mRNA was also inhibited by sesamin. They believe that sesamin inhibits the expression of eNOS gene in endothelial cells, inhibits the expression of ECE gene, and decreases the content of ET-1, thereby inhibiting and regulating blood pressure.

5. Other health functions

In addition to the above physiological activities, it has been reported that sesamin has other health functions. Rat experiments show that sesamin has the effect of inhibiting the breast cancer caused by chemical carcinogens, regulating the immune function, and eliminating the harmful factors of immune cells in the body.

China is rich in sesame resources. It is economically and socially beneficial to the comprehensive development and utilization of sesame seeds and to enhance the value of sesame seeds.